Prednisolone Acetate Injectable Suspension
Brand Name: Prednisolone Acetate Injection
Manufactured by: Intervet / MSD Animal Health
Dosage form: Injectable Suspension
10 ml Vial
Ingredients & Composition:
Each ml of Injectable solution contains
Prednisolone Acetate IP 10 mg
Benzyl Alcohol IP 0.945 % v/v
Description / Action:
Prednisolone crystalline injectable suspension was developed for use in the veterinary field. It has proved to be highly effective in the treatment of acetonemia in cattle (bovine ketosis). Following the injection of prednisolone crystalline suspension, the blood glucose level is restored to normal in short time, appetite and milk yield improves, and circulating ketone bodies return to a normal level. It is 3 to 5 times more active than hydrocortisone, (Natural cortisones) but does not affect mineral balance as that of the other potent corticosteroids.
Class: Steroid / Corticosteroid
Indication / Uses:
Prednisolone injection is indicated for
Treating ketosis in dairy cattle,
Inflammatory and allergic conditions in large and small animal in conjunction with appropriate antibiotic or chemotherapeutic agents when indicated.
Dosage and administration:
For Systemic treatment
Cattle: 50 -100 -200 mg
Calves: 25-50 mg
Piglets, dogs, cats: 10-30 mg
(Dogs and cats – 0.5 to 1.0 mg/kg body weight as an anti-inflammatory while 1-2 mg/kg body weight for immunosuppression q12-24h)
Route: Injection is given deep into muscle
Frequency: 2 – 4 times if necessary at an interval of 24 hours.
For local treatment
Injection is given in the part involved carefully under strict aseptic conditions.
Injection into Joints & tendon sheaths
Large animals: 25-75 mg or more
Dogs & Cats: 5-20 mg or more
Injection into Bursa
10 – 50 mg or more
1.25 – 12.5 mg
Infiltration (as in periostitis etc)
10 – 50 mg
Overdoses / Side effects / Contraindications /Warnings:
Contra Indications include diabetes mellitus & osteoporosis.
In such cases, crystalline suspension must not be administered more than twice. Injections into infected tissues are contraindicated.
Use of prednisolone along with NSAIDs increases the risk of GI ulceration.
Pharmaceutical precautions / Instructions:
The preparation should be shaken well before use, Use fine needle for local therapy. Store protected from light. Not for human use. For animal treatment only.
Safety: Age / Pregnancy/ Withdrawal:
Do not use in pregnant animals.
Meat – Cattle, Sheep & Goat – 5 days & Pig – 28 days
Milk – 3 days
Habit forming: In case of prolonged use as Immunosuppressive/anti-inflammatory dosage should be tapered slowly.
Also See Dexona Injection, Isoflud Injection